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[Diffusion-weighted magnetic resonance imaging of neuro-Behçet's disease]
Abstract:
We report 2 patients (35-year-old and 38-year-old men) with neuro-Behçet's disease and characterize their diffusion-weighted MRI (DWI) findings of brain. T2-weighted and fluid-attenuated inversion recovery images obtained during the acute phase of neurological manifestations demonstrated multiple hyperintense lesions with a characteristic distribution in the brain including brainstem, thalamus, basal ganglia, and cerebral hemisphere. Most of these lesions did not exhibit increased signal intensity on DWI. This MRI profile, especially the combination of isointensity on DWI and hyperintensity on T2-weighted image, of neuro-Behçet's disease is similar to that of multiple sclerosis, and different from that of acute cerebral infarction and herpes simplex encephalitis.
Insights
This study details brain imaging in two men with neuro-Behçet's disease. Their diffusion-weighted MRI (DWI) findings showed lesions that were not bright on DWI, distinguishing it from stroke or encephalitis.
Area of Science:
- Neurology
- Radiology
- Neuroimaging
Background:
- Neuro-Behçet's disease is a rare condition affecting the nervous system.
- Accurate diagnosis relies on characteristic clinical and imaging findings.
Observation:
- Two male patients, aged 35 and 38, with neuro-Behçet's disease were studied.
- Brain MRI, including DWI, T2-weighted, and FLAIR sequences, was performed during acute neurological episodes.
Findings:
- Multiple hyperintense lesions were observed in the brainstem, thalamus, basal ganglia, and cerebral hemispheres on T2-weighted and FLAIR images.
- Crucially, most of these lesions did not show increased signal intensity on diffusion-weighted imaging (DWI).
- This MRI pattern, characterized by isointensity on DWI and hyperintensity on T2-weighted/FLAIR, is distinctive.
Implications:
- The observed MRI profile aids in differentiating neuro-Behçet's disease from other neurological conditions like multiple sclerosis, acute cerebral infarction, and herpes simplex encephalitis.
- This characteristic imaging signature can improve diagnostic accuracy and guide treatment strategies for neuro-Behçet's disease.
- Further research into DWI characteristics in neuroinflammatory conditions is warranted.