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[Juvenile cerebral infarction associated with heparin cofactor II abnormality. A case report].

S Hamasaki¹, M Motomura, S Nakane

¹First Department of Internal Medicine, Nagasaki University School of Medicine.

Rinsho Shinkeigaku = Clinical Neurology

|September 1, 2000

Summary

A young patient experienced a stroke, a rare event in juveniles. Researchers identified a potential link between this cerebral infarction and heparin cofactor II deficiency type II, a condition previously unreported in stroke cases.

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Area of Science:

Neurology
Hematology
Genetics

Background:

Cerebral infarction in adolescents is uncommon.
Identifying novel risk factors for juvenile stroke is crucial for early intervention and prevention.

Observation:

A 15-year-old female presented with acute neurological deficits including right hemiparesis and dysarthria.
MRI revealed a lesion in the left internal capsule.
Laboratory tests showed a prolonged activated partial thromboplastin time and decreased heparin cofactor II activity.

Findings:

The patient was diagnosed with heparin cofactor II deficiency type II, characterized by reduced HC II activity but normal antigen levels.
No mutations were found in the coding region of the heparin cofactor II gene.
The patient's father also exhibited low HC II activity and a history of thromboangiitis obliterans.

Implications:

This case suggests heparin cofactor II deficiency type II may be a potential risk factor for juvenile cerebral infarction.
Further research is warranted to explore the association between HC II deficiency and cerebrovascular events in young individuals.
This finding contributes to understanding the etiologies of stroke in the pediatric and adolescent population.