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[Thyroid function in children with diagnosed chronic hepatitis B treated with interferon alpha].

D M Lebensztejn1, M Kaczmarski, J Wysocka

  • 1III Kliniki Chorób Dzieci AM w Białymstoku.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|September 1, 2000
PubMed
Summary

This study monitored thyroid function in children undergoing interferon alpha therapy for chronic hepatitis B. Results showed normal thyroid hormones and no clinical thyroid dysfunction during treatment.

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Area of Science:

  • Pediatric Endocrinology
  • Hepatology
  • Immunology

Context:

  • Chronic hepatitis B affects children, necessitating antiviral therapies like interferon alpha.
  • Thyroid function can be influenced by various medical treatments.
  • Monitoring endocrine function is crucial during long-term pediatric therapies.

Purpose:

  • To evaluate the impact of interferon alpha therapy on thyroid function in children with chronic hepatitis B.
  • To assess changes in thyroid hormones (FT3, FT4, TSH) and antithyroid antibodies (TPO, ATG) before and after treatment.
  • To identify any subclinical or overt thyroid dysfunction.

Summary:

  • Thyroid function tests (FT3, FT4, TSH) and antithyroid antibody levels (TPO, ATG) were measured in 31 children (aged 4-16) before and after interferon alpha therapy.

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  • All children maintained normal thyroid hormone and ATG concentrations throughout the study.
  • Thyroid peroxidase (TPO) antibodies were detected in a small percentage of patients post-therapy (12.9%), but no clinical thyroid dysfunction was observed.

    • Impact:

    • Interferon alpha therapy appears to have a minimal impact on overall thyroid function in children with chronic hepatitis B.
    • Routine thyroid function monitoring may be warranted, particularly for TPO antibodies, in this patient population.
    • Findings contribute to understanding the safety profile of interferon alpha in pediatric chronic hepatitis B management.