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Some characteristics of human rosette-forming cells
Birth Defects Original Article Series
|January 1, 1975
Summary
This study identifies human rosette-forming cells as thymus and thymus-dependent lymphocytes (T cells). The rosette assay is useful for quantifying T cells in peripheral blood, especially in immunodeficiency diseases.
Area of Science:
- Immunology
- Cell Biology
- Clinical Medicine
Background:
- Rosette-forming cells in humans were investigated.
- The relationship between these cells and lymphocyte populations was unclear.
Purpose of the Study:
- To identify human rosette-forming cells.
- To evaluate the utility of the rosette assay in clinical settings.
Main Methods:
- Application of the rosette assay.
- Analysis of clinical conditions, including primary immunodeficiency diseases.
Main Results:
- Evidence presented identifies rosette-forming cells as thymus and thymus-dependent lymphocytes (T cells).
- The rosette assay demonstrated utility in quantifying T cells.
Conclusions:
- Human rosette-forming cells are confirmed as T cells.
- The rosette assay is a valuable tool for assessing T cell numbers in peripheral blood, particularly in patients with primary immunodeficiency diseases.