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A solid-phase synthesis for beta-turn mimetics of sialyl Lewis X
K Kurokawa1, H Kumihara, H Kondo
1Department of Chemistry, R&D Laboratories, Nippon Organon K.K., Osaka, Japan.
Bioorganic & Medicinal Chemistry Letters
|September 2, 2000
Abstract:
A solid-phase synthesis of heterocyclic beta-turn mimetics of sialyl Lewis X, which is a natural carbohydrate ligand of selectins, was established. This synthetic method could be very useful for drug discovery of selectin antagonists using combinatorial chemistry techniques.