Related Experiment Videos
Synthesis and HIV-1 integrase inhibitory activities of caffeoylglucosides
1Division of Life Sciences, Korea Institute of Science and Technology, Seoul, South Korea.
Bioorganic & Medicinal Chemistry Letters
|September 2, 2000
Abstract:
Caffeoylglucosides, which have a glucose ring as a central linker, were synthesized from methyl D-glucosides, and their anti-HIV-1 activities were tested. Among them, four dicaffeoylglucosides (IC50 = 29.1+/-35.1 microM), 6a, 6b, 9b and 10b, showed HIV-1 integrase inhibitory activity as potent as L-chicoric acid.