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HIV-1 integrase inhibitory phenylpropanoid glycosides from Clerodendron trichotomum
1Division of Life Sciences, Korea Institute of Science & Technology, Seoul.
Archives of Pharmacal Research
|September 6, 2001
Abstract:
Seven phenylpropanoid glycosides named acteoside (1), acteoside isomer (2), leucosceptoside A (3), plantainoside C (4), jionoside D (5), martynoside (6), and isomartynoside (7) were isolated from Clerodendron trichotomum. Compounds 1 and 2 showed potent inhibitory activities against HIV-1 integrase with IC50 values of 7.8 +/- 3.6 and 13.7 +/- 6.0 microM, respectively.