[Misleading or rare cutaneous drug reactions]

Drug hypersensitivity syndrome and drug-induced cutaneous pseudolymphoma were for a long time considered as one and the same. Today, however, two clinical entities have been distinguished; the former is responsible for a mortality rate estimated at 10% whereas the prognosis of the latter is always excellent. Acute generalized exanthematous pustulosis is a rare drug eruption individualised in 1980. Numerous drugs can induce acneiform eruptions or trigger or even worsen an authentic acne. The number of drugs responsible for buccal mucous membrane involvement is on the increase; gingival hypertrophy remains a rare drug reaction, a certain number of drugs such as nicorandil can cause buccal aphtae and even giant ones.