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Bone mineral density, vitamin D and anticonvulsant therapy
S Filardi1, C A Guerreiro, L A Magna
1Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Brazil.
Unlabelled:
The aim of this study was to assess bone mineral density and vitamin D metabolism in patients on chronic anticonvulsant therapy.
Methods:
Sixty-nine men, outpatients on chronic anticonvulsant therapy, who had been treated for at least 5 years, were studied, comparing them to thirty healthy controls. Bone mineral density was measured as well as serum levels of calcium, ionized calcium, alkaline phosphatase, PTH, 25-hydroxycholecalciferol and 1, 25-dihydroxycholecalciferol.
Results:
No differences in bone mineral density, serum levels of vitamin D and intact-PTH were observed between patients and controls. Bone mineral density was not associated with chronic anticonvulsant therapy.
Conclusion:
Those adult patients who were on chronic anticonvulsant therapy and who lived in low latitude regions had normal bone mineral density as well as vitamin D serum levels.