Amino acid substitution within the S2 and S4 transmembrane segments in Shaker potassium channel modulates channel

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Updated: Jul 5, 2026

Mutagenesis and Functional Analysis of Ion Channels Heterologously Expressed in Mammalian Cells
15:28

Mutagenesis and Functional Analysis of Ion Channels Heterologously Expressed in Mammalian Cells

Published on: October 1, 2010

M H Wang1, U Oh, H I Rhee

  • 1Department of Life Science, Pohang University of Science and Technology, Pohang, Kyun-Buk, 790-784, Korea. mhwang@postech.ac.kr

Biochemical and Biophysical Research Communications
|September 7, 2000
PubMed

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Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
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Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
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Mechanically-gated Ion Channels

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Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
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