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Updated: Aug 13, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Lymphocyte peripheral benzodiazepine receptor mRNA decreases in obsessive-compulsive disorder
1Department of Neuroscience, Section of Psychiatry, University of Turin, via Cherasco 11, 10126 Torino, Italy. milani@molinette.unito.it
Abstract:
The relative content of peripheral benzodiazepine receptor (pBR) mRNA was examined by reverse transcriptase-polymerase chain reaction in lymphocytes of obsessive-compulsive disorder (OCD) patients, according to their clinical course of illness. pBR mRNA significantly decreased only in chronic OCD patients (n=8) as compared to controls (n=10), whereas no significant changes were observed in episodic OCD patients (n=7). We suggest that modulation of pBR gene expression might delineate a clinical heterogeneity in OCD.
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