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Palatable fluids do not affect alcohol intake and its reduction by serotonergic compounds in alcohol-preferring cAA
S Maurel1, R Schreiber, J De Vry
1CNS Research, Bayer AG, Aprather Weg 18 a, D-42096, Wuppertal, Germany.
Abstract:
1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI) decreases alcohol intake by alcohol-preferring cAA rats more selectively than fluoxetine in a two-bottle alcohol vs. water paradigm. We report now that availability of sucrose or saccharin in a 3rd bottle does not affect (1) alcohol intake, supporting further the validity of this model of alcoholism, nor (2) the selectivity profile of the alcohol intake-reducing effects of these compounds. It is hypothesized that reduction of alcohol intake by DOI is not simply due to decreased intake of palatable fluids.