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Effect of pineal tetrapeptide on antioxidant defense in Drosophila melanogaster
1St. Petersburg Institute of Biological Regulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences.
Bulletin of Experimental Biology and Medicine
|September 8, 2000
Abstract:
Effects of synthetic pineal tetrapeptide L-Ala-L-Glu-L-Asp-L-Glu (Epithalon) on specific catalase activity and the content of conjugated hydroperoxides in highly inbred Drosophila melanogaster lines differing in reproductive functions were studied. It was shown that Epithalon is a potent modulator of the antioxidant defense, whose biological activity 1000-fold surpasses that of the complex pineal peptide preparation Epithalamin.