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Efficacy of Interferon-Gamma (Ingaron) against Experimental Tuberculosis in BALB/c Mice
I A Vasilyeva1, A G Samoylova1, V V Avdeev1
1National Medical Research Center of Phthisiopulmology and Infectious Diseases, Ministry of Health of the Russian Federation, Moscow, Russia.
Abstract:
The therapeutic activity of an IFN-γ preparation Ingaron, both alone and in combination with isoniazid, was studied in an experimental model of tuberculosis infection in inbred BALB/c mice. The combination of oral isoniazid and subcutaneous IFN-γ administration demonstrated high efficacy, which was confirmed by microbiological and morphological examination of the lungs and spleens, as well as by the organ weight dynamics.
