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IgCAMs: bidirectional signals underlying neurite growth

H Kamiguchi1, V Lemmon

  • 1Developmental Brain Science Group, RIKEN Brain Science Institute (BSI), 2-1 Hirosawa, Saitama 351-0198, Wako, Japan. kamiguchi@brain.riken.go.jp

Current Opinion in Cell Biology
|September 9, 2000
PubMed

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...