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Current status of thromboangiitis obliterans (Buerger's disease) in Japan

S Sasaki1, M Sakuma, K Yasuda

  • 1Department of Cardiovascular Surgery, Hokkaido University School of Medicine, N-14, W-5, Kita-ku, 0608648, Sapporo, Japan. sasakish@med.hokudai.ac.jp

International Journal of Cardiology
|September 12, 2000
PubMed

Insights

Thromboangiitis obliterans (TAO) patients who stop smoking have significantly reduced risks of ulcers and amputations. Abstinence from tobacco improves quality of life for individuals with TAO.

Area of Science:

  • Vascular Medicine
  • Rheumatology
  • Clinical Epidemiology

Background:

  • Thromboangiitis obliterans (TAO), also known as Buerger's disease, is a rare inflammatory condition affecting small and medium-sized blood vessels, primarily in the limbs.
  • Understanding the clinical features and outcomes of TAO is crucial for effective patient management and treatment strategies.

Purpose of the Study:

  • To analyze the clinical manifestations and outcomes of a large cohort of patients diagnosed with thromboangiitis obliterans (TAO).
  • To identify factors influencing disease progression, such as smoking cessation, and their impact on ulcer formation and amputation risk.

Main Methods:

  • Analysis of clinical data from 850 patients with TAO, sourced from the 1993 Nationwide Survey of Vasculitis database in Japan.
  • Assessment of clinical manifestations using Fontaine's classification, lesion distribution, treatment responses, and patient outcomes.
  • Statistical analysis to determine the impact of smoking cessation on ulcer formation and amputation rates.

Main Results:

  • The study included 850 patients (90.7% male), with a mean age of 50.8 years.
  • Clinical presentations ranged from Fontaine I (8.0%) to Fontaine IV (38.1%), with significant symptom improvement noted.
  • Failure to cease smoking was a significant risk factor for ulcer formation (OR=1.71) and amputation (OR=2.73).
  • Female patients had a higher proportion of non-smokers compared to males, with similar clinical features otherwise.

Conclusions:

  • Abstinence from tobacco is a critical factor in reducing the risk of ulcer formation and amputation in patients with TAO.
  • Smoking cessation significantly improves the quality of life for individuals suffering from thromboangiitis obliterans.
  • Early intervention and support for smoking cessation are paramount in managing TAO.

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