Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Insulin and the vasculature.

N Mikhail1, M L Tuck

  • 1Department of Veterans Affairs Medical Center, Endocrinology Section 111-E, 16111 Plummer Street, Sepulveda, CA 91343, USA.

Current Hypertension Reports
|September 12, 2000
PubMed
Summary

Insulin normally protects blood vessels by promoting vasodilation. In insulin resistance, this protective effect is impaired, potentially linked to endothelial dysfunction and increased arterial stiffness.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A simple bedside blood test (Fibrofast; FIB-5) is superior to FIB-4 index for the differentiation between non-significant and significant fibrosis in patients with chronic hepatitis C.

Hepatology international·2017
Same author

Two-year results of a randomised double-blinded trial evaluating silymarin for chronic hepatitis C.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2005
Same author

Randomised double-blinded trial evaluating silymarin for chronic hepatitis C in an Egyptian village: study description and 12-month results.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2004
Same author

Severe hypocalcemia: a rare cause of reversible heart failure.

Congestive heart failure (Greenwich, Conn.)·2002
Same author

Familial obesity, sympathetic activation and blood pressure level.

Blood pressure·2002
Same author

Differences in mechanisms between weight loss-sensitive and -resistant blood pressure reduction in obese subjects.

Hypertension research : official journal of the Japanese Society of Hypertension·2001

Area of Science:

  • Cardiovascular physiology
  • Endocrinology
  • Vascular biology

Background:

  • Physiologic insulin promotes vasodilation via nitric oxide synthesis.
  • Insulin may reduce vascular smooth muscle cell (VSMC) contraction by lowering intracellular calcium.
  • Insulin resistance syndrome is linked to endothelial dysfunction and impaired insulin's vasodilatory effects.

Purpose of the Study:

  • To explore the vasculoprotective roles of insulin.
  • To investigate the impact of insulin resistance on vascular function.
  • To examine the relationship between insulin resistance, arterial properties, and potential therapeutic interventions.

Main Methods:

  • Review of insulin's physiological actions on the vasculature.
  • Analysis of the link between insulin resistance and endothelial dysfunction.
  • Correlation of insulin resistance with carotid artery wall thickness and stiffness.
  • Assessment of insulin's role as a growth factor for VSMCs.

Main Results:

  • Insulin's vasodilatory and VSMC-calming effects are established under normal conditions.
  • Insulin resistance may blunt insulin's beneficial vasodilatory actions.
  • Insulin resistance correlates with increased carotid artery thickness and stiffness, with sex and ethnic modifications.
  • Insulin can stimulate VSMC growth.

Conclusions:

  • Endothelial dysfunction in insulin resistance may impair insulin's protective vasodilatory effects.
  • Insulin resistance is associated with adverse vascular remodeling.
  • Insulin-sensitizing agents show promise in mitigating vascular pathology in insulin resistance.

Related Experiment Videos