Related Experiment Videos
Creation of aortic dissection model in swine
1Department of Thoracic and Cardiovascular Surgery, Kansai Medical University, Osaka, Japan.
Japanese Circulation Journal
|September 12, 2000
Summary
Creating a thoracic aortic dissection model in swine is feasible. Avoid pentobarbital anesthesia and descending aortic cross-clamping to prevent mortality in this swine model for aortic dissection research.
Area of Science:
- Cardiovascular Research
- Surgical Models
- Animal Research
Background:
- Mongrel dog use in research is restricted.
- Need for alternative animal models for aortic dissection studies.
Purpose of the Study:
- Establish a swine model for thoracic aortic dissection.
- Evaluate anesthetic and surgical techniques.
Main Methods:
- Swine underwent aortic dissection creation.
- Group 1: No pentobarbital, descending aorta side-clamped.
- Group 2: Pentobarbital anesthesia used.
Main Results:
- Swine without pentobarbital maintained a patent false lumen long-term.
- All swine receiving pentobarbital died from heart failure.
- Successful creation of a thoracic aortic dissection model in swine.
Conclusions:
- Thoracic aortic dissection model creation is possible in swine.
- Pentobarbital anesthesia and descending aorta cross-clamping should be avoided.
- This model offers an alternative for aortic dissection research.