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Abdominal multivisceral transplantation in pigs
T Komokata1, S Nishida, S Ogata
1Second Department of Surgery, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8520, Japan.
Journal of Hepato-Biliary-Pancreatic Surgery
|September 12, 2000
Summary
Pigs underwent abdominal multivisceral transplantation without immunosuppression, facing high mortality from complications like respiratory insufficiency and circulatory shock. Despite challenges, the procedure is deemed practical for future research into organ rejection and complex graft interactions.
Area of Science:
- Surgical Innovation
- Transplantation Immunology
- Veterinary Medicine
Background:
- Porcine models are crucial for advancing complex transplantation research.
- Understanding pathophysiological responses in multivisceral grafts is essential.
- Technical challenges in abdominal multivisceral transplantation require investigation.
Purpose of the Study:
- To evaluate the technical feasibility and outcomes of porcine abdominal multivisceral transplantation.
- To identify early complications and survival rates in non-immunosuppressed recipients.
- To explore the potential of this model for studying immunologic aspects and organ interrelationships.
Main Methods:
- Orthotopic transplantation of liver, pancreas, and gastrointestinal tract in pigs.
- In situ flushing and cold storage of multivisceral grafts using University of Wisconsin solution.
- Observation of pathophysiological features and survival in 18 non-immunosuppressed recipients.
Main Results:
- 50% mortality within 24 hours due to respiratory insufficiency and circulatory shock.
- 17% mortality from acute renal failure by postoperative day 5.
- 33% survival beyond 1 week, with late deaths from bowel obstruction, pneumonia, and graft rejection.
Conclusions:
- Abdominal multivisceral transplantation in pigs presents significant technical and immunological challenges.
- High early mortality necessitates further research into immunosuppression and organ preservation.
- The porcine model remains a viable platform for investigating complex transplantation issues.