Related Experiment Video
Updated: Aug 18, 2026

A Modified In vitro Invasion Assay to Determine the Potential Role of Hormones, Cytokines and/or Growth Factors in Mediating Cancer Cell Invasion
Published on: April 24, 2015
The question of a link between insulin-like growth factor physiology and neoplasia
1Cancer Prevention Research Unit, Lady Davis Research Institute of the Jewish General Hospital and McGill University, Montreal, Quebec, Canada. MD49@musica.mcgill.ca
Abstract:
The results of both population and laboratory studies suggest that the physiology of insulin-like growth factors (IGFs) has important influences on cancer biology and cancer risk. This review highlights recent laboratory and epidemiological results in this rapidly evolving area of investigation. There is no direct evidence to suggest that growth hormone (GH) treatment of GH-deficient patients increases their risk of neoplasia, but recent research reinforces the need for careful surveillance. The monitoring of serum IGF-I levels may be advisable to help avoid inadvertent over-treatment, particularly in individuals undergoing long-term GH replacement therapy.
More Related Videos
09:52A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
Published on: September 20, 2016
06:25Ex Vivo Culture of Circulating Tumor Cells in the Cerebral Spinal Fluid from Melanoma Patients to Study Melanoma-Associated Leptomeningeal Disease
Published on: March 29, 2024
Related Concept Videos
Mitogens and the Cell Cycle
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Regulation of Angiogenesis and Blood Supply
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
PI3K/mTOR/AKT Signaling Pathway
Insulin: The Receptor and Signaling Pathways