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Structures of photointermediates and their implications for the proton pump mechanism
1Department of Materials Science, Nara Institute of Science and Technology, 8916-5, Takayama-machi, Ikoma, Nara 630-0101, Japan. kataoka@ms.aist-hara.ac.jp
Biochimica Et Biophysica Acta
|September 14, 2000
Abstract:
It is widely accepted that bacteriorhodopsin undergoes global conformational changes during its photocycle. In this review, the structural properties of the M and N intermediates are described in detail. Based on the clarified global conformational change, we propose a model for the molecular mechanism of the proton pump. The global structural change is suggested to be a key component in establishing vectorial proton transport.