Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cyclin transcription: Timing is everything.

L L Breeden1

  • 1Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA. lbreeden@fhcrc.org

Current Biology : CB
|September 14, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early cell cycle box-mediated transcription of CLN3 and SWI4 contributes to the proper timing of the G(1)-to-S transition in budding yeast.

Molecular and cellular biology·2001
Same author

Mutation and modeling analysis of the Saccharomyces cerevisiae Swi6 ankyrin repeats.

Biochemistry·1998
Same author

Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae.

Genes & development·1997
Same author

A novel Mcm1-dependent element in the SWI4, CLN3, CDC6, and CDC47 promoters activates M/G1-specific transcription.

Genes & development·1997
Same author

Cell cycle-dependent transcription of CLN1 involves swi4 binding to MCB-like elements.

The Journal of biological chemistry·1997
Same author

A new Saccharomyces cerevisiae ankyrin repeat-encoding gene required for a normal rate of cell proliferation.

Gene·1996
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Tracking Satb2-positive retinal ganglion cells in zebrafish unveils developmental functional reorganization.

Current biology : CB·2026
Same journal

RhoGAP54D promotes cell size asymmetry and inhibits pulsatile myosin activity in Drosophila neural stem cells.

Current biology : CB·2026
Same journal

Increased rates of hybridization in swordtails are associated with water pollution.

Current biology : CB·2026
Same journal

Visual uncertainty and task demands shape active sensing strategies in mice.

Current biology : CB·2026
See all related articles

Cyclin-dependent kinases control cell-cycle transitions. New research reveals how budding yeast

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Cell-cycle progression is tightly regulated by stage-specific activation of cyclin-dependent kinases (CDKs).
  • Understanding the precise mechanisms governing cell-cycle transitions is crucial for comprehending cellular function and dysfunction.
  • Mitotic cyclins play a pivotal role in driving cells through mitosis.

Purpose of the Study:

  • To elucidate the regulatory mechanisms underlying cell-cycle-controlled transcription of mitotic cyclins in budding yeast.
  • To provide detailed insights into how CDK activity influences gene expression during the cell cycle.

Main Methods:

  • Utilized budding yeast (Saccharomyces cerevisiae) as a model organism.
  • Employed molecular biology techniques to analyze gene expression patterns.

Related Experiment Videos

  • Investigated the role of cyclin-dependent kinases in transcriptional regulation.

    • Main Results:

    • Identified key regulatory elements controlling mitotic cyclin transcription.
    • Demonstrated a direct link between CDK activity and the timing of mitotic cyclin gene expression.
    • Uncovered specific mechanisms by which cell-cycle progression influences transcription.

    Conclusions:

    • The findings offer a deeper understanding of cell-cycle control in budding yeast.
    • Highlights the intricate relationship between protein kinase activity and transcriptional regulation.
    • Provides a foundation for future research into cell-cycle dynamics and potential therapeutic targets.