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A fraction isolated from Ehrlich ascites carcinoma as an antitumor and differentiating agent against human leukemic
1Department of Pharmacology and Experimental Therapeutics, Indian Institute of Chemical Biology, Jadavpur University, Calcutta. iichbio@sias101.vsnl.net.in
Neoplasma
|September 14, 2000
Abstract:
Lipopolysaccharide fraction isolated from Ehrlich ascites carcinoma (E-LPS) was investigated as an antitumor agent against human leukemia cell ML-2. Marked cell growth inhibition was observed with ML-2 cell accompanied by inhibition of DNA synthesis and perturbation of cell cycle. Induction of differentiation in treated ML-2 cells was observed as indicated by morphological maturation, NBT reducing activity and indirect immunofluorescence.