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Towards enzyme activated antiprostatic agents
G B Jones1, M O Mitchell, J S Weinberg
1Department of Chemistry, Northeastern University, Boston, MA 02115, USA. grjones@lynx.neu.edu
Bioorganic & Medicinal Chemistry Letters
|September 15, 2000
Abstract:
A prodrug conjugate designed to undergo activation by enzymatic prostate specific antigen has been synthesized. The prodrug system undergoes activation with PSA or alpha-chymotrypsin, and shows selective cytotoxicity in a PSA secreting cell line.