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2'-Deoxy-8-(propyn-1-yl)adenosine-containing oligonucleotides: effects on stability of duplex and quadruplex
B Catalanotti1, A Galeone, L Gomez-Paloma
1Dip. di Chimica delle Sostanze Naturali, Univ. di Napoli Federico II, Italy.
Bioorganic & Medicinal Chemistry Letters
|September 15, 2000
Abstract:
2'-Deoxy-8-(propyn-1-yl)adenosine has been incorporated in synthetic oligodeoxyribonucleotides and its influence on thermal stability of duplex and quadruplex structures investigated by UV, CD and 1H NMR. The obtained results seem to indicate that the presence of the modified base negatively affects the stability of double stranded DNA whereas remarkably increases the stability of parallel quadruplex structures.