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Related Experiment Videos

Cortical function in epilepsy.

W D Gaillard1

  • 1Department of Neurology, Children's National Medical Center, The George Washington University, School of Medicine, Washington, DC, USA. gaillardw@ninds.nih.gov

Current Opinion in Neurology
|September 15, 2000
PubMed
Summary
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Functional neuroimaging techniques like PET and fMRI are mapping brain functions, offering alternatives to invasive methods. These advanced tools are crucial for understanding language and memory localization in the brain.

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Cognitive Science

Background:

  • Functional neuroimaging, including (15)O water positron emission tomography (PET) and functional magnetic resonance imaging (fMRI), has advanced the understanding of brain function.
  • These techniques are emerging as less invasive alternatives to the intracarotid amytal procedure for assessing brain lateralization.

Purpose of the Study:

  • To review the application of functional neuroimaging in localizing and lateralizing language functions.
  • To highlight the development of paradigms for assessing memory capacity in the hippocampus and mesial temporal structures.
  • To discuss the potential of magnetoelectroencephalography (MEE) for real-time language mapping and event-related data acquisition for localizing interictal activity.

Main Methods:

  • Utilizing (15)O water positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to map blood flow changes.

Related Experiment Videos

  • Designing specific paradigms and sequences to evaluate memory functions in key brain structures.
  • Employing magnetoelectroencephalography (MEE) for real-time functional brain mapping.
  • Applying event-related data acquisition techniques to pinpoint blood flow alterations linked to interictal events.

    • Main Results:

    • PET and fMRI have successfully identified the lateralization and location of language functions.
    • Specialized paradigms are being developed to assess the memory capabilities of the hippocampus and mesial structures.
    • Magnetoelectroencephalography shows promise for real-time language mapping.
    • Event-related data acquisition aids in localizing blood flow changes associated with interictal activity.

    Conclusions:

    • Functional neuroimaging techniques provide valuable insights into brain function, particularly for language and memory.
    • These non-invasive methods are increasingly replacing traditional invasive procedures.
    • Emerging technologies like MEE offer new possibilities for dynamic brain mapping and clinical applications.