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Development of a solution-phase synthesis of minor groove binding bis-intercalators based on triostin A suitable for
1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. boger@scripps.edu
The Journal of Organic Chemistry
|September 16, 2000
Abstract:
The development of a solution phase synthesis of azatriostin A (2) suitable for the preparation of combinatorial libraries enlisting only liquid-liquid acid/base extractions for the isolation and purification of all intermediates and the final product is disclosed.