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[Anti-angiogenesis strategies in cancer]
1GDR CNRS 1927 Angiogenèse, Toulouse.
Abstract:
It is generally accepted that tumor development requires the secretion by cancer cells of soluble mediators which activate the formation of new vessels, called "Tumor Angiogenic Factors". The intense quest for identifying these factors has recently been confirmed by strong experimental data. The discovery in 1989 of the Vascular Endothelial Growth Factor VEGF and of new proteases had led to the identification of the key actors of tumor angiogenesis. The elucidation of their mechanisms of action allowed to design new therapeutic strategies already confirmed by preclinical trials. There are now almost twenty molecules which are under clinical investigation in man.
Insights
Tumor growth relies on tumor angiogenic factors that promote new blood vessel formation. Identifying key factors like Vascular Endothelial Growth Factor (VEGF) has enabled new therapeutic strategies for cancer.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Context:
- Tumorigenesis necessitates the development of new blood vessels.
- Tumor Angiogenic Factors (TAFs) secreted by cancer cells drive this process.
- Identifying these factors is crucial for understanding cancer progression.
Purpose:
- To review the identification and mechanisms of key tumor angiogenic factors.
- To highlight the role of Vascular Endothelial Growth Factor (VEGF) and proteases.
- To discuss the development of novel therapeutic strategies based on these discoveries.
Summary:
- The discovery of VEGF and proteases in 1989 significantly advanced the identification of key players in tumor angiogenesis.
- Understanding the mechanisms of action of these factors has been pivotal.
- Numerous molecules involved in tumor angiogenesis are now under clinical investigation.
Impact:
- Elucidated mechanisms have paved the way for innovative anti-cancer therapies.
- Preclinical trials have validated these new therapeutic strategies.
- Ongoing clinical investigations show promise for future cancer treatment options.