Related Experiment Video
Updated: Oct 13, 2026

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva
Published on: April 3, 2018
Hepatocyte growth factor is a predominant chemoattractant for gingival epithelial cells produced by radicular
M Ohshima1, T Nishiyama, Y Yamazaki
1Department of Biochemistry, Nihon University School of Dentistry, Tokyo, Japan.
Abstract:
To clarify whether fibroblasts could be involved in the pathogenesis of periodontal pocket formation, the chemotactic activity of radicular cyst-derived fibroblast-like cell (RCF)-conditioned medium (RCF-CM) for gingival epithelial cells was examined using a modified Boyden chamber assay. RCF-CM possessed significant chemotactic activity, which was decreased markedly by treatment with anti-human hepatocyte growth factor (HGF) antibody. Furthermore, the chemotactic activity of RCF-CM was well correlated with HGF content. These results show that the RCF secrete an HGF-like factor, and suggest that such a factor derived from periodontal fibroblasts might play a role in epithelial apical migration in periodontitis.
Related Concept Videos
Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Regulation of Hematopoietic Stem Cells
Healing I: Introduction
Small GTPases - Ras and Rho
Three regulatory proteins control their activity:
Differentiation of Common Myeloid Progenitor Cells
Regulation of Angiogenesis and Blood Supply
