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Regulation of the epithelial sodium channel (ENaC) by accessory proteins
1The Hospital for Sick Children, and Biochemistry Department, University of Toronto, Ontario, Canada. drotin@sickkids.on.ca
Current Opinion in Nephrology and Hypertension
|September 16, 2000
Abstract:
The epithelial sodium channel (ENaC) plays a key role in the regulation of fluid absorption in the kidney, lung, colon and exocrine glands, and in the regulation of blood pressure. Abnormal functioning of ENaC is associated with several human diseases, including pseudohypoaldosteronism type I, Liddle's syndrome, pulmonary edema, and cystic fibrosis. ENaC is regulated by several hormones, ions and accessory proteins. This review focuses on the regulation of ENaC by recently described accessory proteins, mainly Nedd4, syntaxin 1A, CFTR, sgk, K-Ras2A and Cap-1.