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Beta blockade in lithium tremor.

J M Kellett, M Metcalfe, J Bailey

    Journal of Neurology, Neurosurgery, and Psychiatry
    |July 1, 1975
    PubMed
    Summary
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    Beta-blocking agents like practolol and propranolol worsen lithium-induced tremor compared to placebo. This suggests lithium tremor resembles essential tremor more than physiological tremor.

    Area of Science:

    • Neuropharmacology
    • Clinical Neurology

    Background:

    • Lithium is a common mood stabilizer associated with tremor side effects.
    • The exact nature of lithium-induced tremor is not fully understood.
    • Distinguishing between different tremor types is crucial for effective management.

    Purpose of the Study:

    • To investigate the effect of beta-blocking agents on lithium-induced tremor.
    • To compare lithium-induced tremor with essential and physiological tremor.

    Main Methods:

    • An objective tremor assessment was used.
    • Practolol and propranolol were administered to participants with lithium-induced tremor.
    • A placebo group was included for comparison.

    Main Results:

    Related Experiment Videos

    • Both practolol and propranolol significantly increased tremor severity compared to placebo.
    • This indicates a potential interaction between beta-blockers and lithium's tremorigenic effect.

    Conclusions:

    • Lithium-induced tremor may share pathophysiological mechanisms with essential tremor.
    • Beta-blocking agents may exacerbate, rather than alleviate, lithium-induced tremor.