Related Experiment Video
Updated: Aug 2, 2026
Murine Fetal Echocardiography
Published on: February 15, 2013
[Sensitive and specific screening for detection of spina bifida by echography in the second trimester; systematic
J M Vos1, M Offringa, C M Bilardo
1Afd. Kindergeneeskunde, Academisch Medisch Centrum/Emma Kinderziekenhuis, DE Amsterdam. m.offringa@amc.uva.nl
Objective:
Evaluation of the diagnostic accuracy of ultrasound in the second trimester for the detection of spina bifida.
Design:
Systematic review and meta-analysis.
Method:
Medline and Embase were searched to identify prospective studies in a general pregnant population. Also, in the Cochrane Library, references of identified reports and recent reviews were checked for relevant studies. Retrieved abstracts were selected independently by 2 authors using predefined criteria. Assessment of quality and generalizability of the included studies and data extraction were performed by 3 authors independently. The data were tested for heterogeneity and pooled estimates of sensitivity and specificity were calculated for all studies.
Results:
13 studies were included. Specificity was approximately 100% in all cases. Sensitivity varied from 40% to 100%. The summary point estimate for sensitivity was 71% with a 95% confidence interval of 59%-81%.
Conclusion:
Ultrasound in the second trimester is a specific investigation to detect spina bifida, which may detect seven out of ten defects. Used as a screening tool, it could contribute to a significant reduction in the number of children born with spina bifida.
