Related Experiment Videos

Synthesis of the spirosuccinimide moiety of Asperparaline A

S Tanimori¹, K Fukubayashi, M Kirihata

¹Department of Applied Biochemistry, College of Agriculture, Osaka Prefecture University, Sakai, Japan. tanimori@biochem.osakafu-u.ac.jp

Bioscience, Biotechnology, and Biochemistry

|September 19, 2000

Abstract:

2,6,6-Trimethyl-2-azaspiro[4.4]nonane-1,3-dione (9), a spirosuccinimide moiety of asperparaline A (1), was synthesized by starting from 2,2-dimethylcyclopentanone (4) via trinitrile 6 in five steps in a moderate yield. This conversion establishes a model study for synthesis of the spirosuccinimide moiety of asperparaline A (1).

Related Concept Videos

Articles linked to this work by shared authors, journal, and citation graph.

Simple Synthesis of Both Enantiomers of the C7-C12 Segment of Epothilones.

Bioscience, biotechnology, and biochemistry·2016

Effects of Sugar Acids on the Functions of Ribulose Bisphosphate Carboxylase/Oxygenase: Differentiation of Two Different Ligand-binding Modes of the Catalytic Sites.

Bioscience, biotechnology, and biochemistry·2016

Synthesis of (E)-δ-hydroxy-β,γ-dehydroα-amino acids, a new class of vinylglycines by the rearrangement ofβ acetoxyallylglycine derivatives.

Amino acids·2013

Boron neutron capture therapy for clear cell sarcoma (CCS): biodistribution study of p-borono-L-phenylalanine in CCS-bearing animal models.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2011

Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2011

Evaluation of the potential of p-boronophenylalaninol as a boron carrier in boron neutron capture therapy, referring to the effect on intratumor quiescent cells.

Japanese journal of cancer research : Gann·2001

See all related articles