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First synthesis of a alpha-trifluoromethyl allenol ether via the Julia-Lythgoe process
1Department of Chemistry, Faculty of Education, Gifu University, Japan. yoshimae@cc.gifu-u.ac.jp
Chemical & Pharmaceutical Bulletin
|September 19, 2000
Abstract:
Alpha-trifluoromethyl allenol ethers 9a-e were prepared in moderate to good yields by the Julia-Lythgoe process using beta-ethoxy-beta-trifluoromethyl vinylic sulfone 3. Several reactions of 9c were examined to give alpha,beta-unsaturated trifluoromethyl ketone derivatives 11 and 12.