Ketoprofen (Orudis) in ankylosing spondylitis

Area of Science:

• Rheumatology
• Pharmacology

Background:

• Ankylosing spondylitis is a chronic inflammatory condition.
• Phenylbutazone is a common treatment for ankylosing spondylitis.

Purpose of the Study:

• To compare the efficacy and patient preference of ketoprofen versus phenylbutazone in ankylosing spondylitis patients.

Main Methods:

• A double-blind, cross-over study design.
• 14 patients with ankylosing spondylitis participated.
• Ketoprofen (Orudis) was compared against phenylbutazone.

Main Results:

• Patients showed a significant preference for phenylbutazone.
• Phenylbutazone led to greater improvement in Erythrocyte Sedimentation Rate (ESR).
• Ketoprofen did not result in objective or laboratory deterioration.

Conclusions:

• Ketoprofen may serve as a viable alternative to phenylbutazone for treating ankylosing spondylitis.
• Further research is warranted to confirm ketoprofen's long-term efficacy and safety in spondylitic disease.