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Related Experiment Videos

Lipid phosphatases in the immune system.

G Krystal1

  • 1Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada V5Z 1L3. gerry@terryfox.ubc.ca

Seminars in Immunology
|September 21, 2000
PubMed
Summary

Phosphatidylinositol (PI)-3,4,5-P(3) is crucial for cellular responses. This review summarizes key phosphatases (SHIP, SHIP2, PTEN) regulating its levels.

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Background:

  • Phosphatidylinositol (PI)-3,4,5-P(3) is a key signaling phospholipid.
  • Its levels rise upon growth factor stimulation via PI-3-kinase activation.
  • PI-3,4,5-P(3) regulates diverse biological responses to extracellular signals.

Purpose of the Study:

  • To review the current knowledge on three key enzymes regulating PI-3,4,5-P(3) levels.
  • To summarize the cloning and function of SHIP, SHIP2, and PTEN phosphatases.
  • To highlight the role of these phosphatases in cellular signaling.

Main Methods:

  • Literature review of recent studies on SHIP, SHIP2, and PTEN.
  • Analysis of the role of these phosphatases in regulating PI-3,4,5-P(3) levels.
  • Synthesis of current understanding of their biological functions.

Main Results:

  • SHIP, SHIP2, and PTEN have been cloned within the last three years.
  • These enzymes play critical roles in controlling the cellular concentration of PI-3,4,5-P(3).
  • Their activity is essential for modulating cellular responses.

Conclusions:

  • SHIP, SHIP2, and PTEN are vital regulators of the PI-3,4,5-P(3) signaling pathway.
  • Understanding these phosphatases provides insight into cellular signaling.
  • Further research into these enzymes will elucidate their full biological significance.

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