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Automatic Detection of Highly Organized Theta Oscillations in the Murine EEG

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Acute hypoxia activates human 8-12 Hz physiological tremor.

W L Krause¹, J C Leiter, S Marsh Tenney

¹Medical Services, Pulmonary and Critical Care Unit, Massachusetts General Hospital and Harvard Medical School, Bulfinch 148, 55 Fruit Street, Boston, MA 02114, USA. wkrause@partners.org

Respiration Physiology

|September 21, 2000

Summary

Hypoxia, a state of low oxygen, significantly increases physiological tremor in humans. This effect is further amplified by hypocapnia, or low carbon dioxide levels, in some individuals.

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Area of Science:

Physiology
Neuroscience
Human Performance

Background:

Hypoxia is known to induce arousal.
The somatomotor system's response to hypoxia requires further investigation.
Tremor augmentation during hypoxia has been hypothesized.

Purpose of the Study:

To investigate the effects of hypoxia on the human somatomotor system.
To determine the impact of hypoxia and hypocapnia on finger tremor.
To examine the interaction between hypocapnia and hypoxia on tremor.

Main Methods:

12 healthy male volunteers participated.
Five conditions were tested: eupnea, hypocapnic hypoxia, eucapnic hypoxia, hypocapnic normoxia, and eucapnic normoxia.
Finger tremor was quantified using acceleration power spectra (8-12 Hz).

Main Results:

Acute hypoxia significantly augmented 8-12 Hz physiological tremor (P=0.002).
50% of subjects showed increased tremor during hypocapnic hypoxia compared to eucapnic hypoxia.
Hypocapnia exacerbated hypoxia-induced tremor in a subset of participants.

Conclusions:

Acute hypoxia demonstrably augments physiological tremor.
Hypocapnia can further increase tremor during hypoxia in some individuals.
Activated physiological tremor during hypoxia may involve spinal alpha-motoneuron entrainment.