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Related Experiment Videos

Lymphokines in rheumatoid synovitis.

P Stastny, M Rosenthal, M Andreis

    Annals of the New York Academy of Sciences
    |June 13, 1975
    PubMed
    Summary

    Soluble factors, like lymphokines, released from inflamed joints may cause inflammatory arthritis changes. These factors, including macrophage migration inhibitory factor, are found in rheumatoid arthritis synovial fluids and can induce synovitis in rabbits.

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    Area of Science:

    • Immunology
    • Rheumatology
    • Cell Biology

    Background:

    • Inflamed synovial tissues release macrophage migration inhibitory factor.
    • Human rheumatoid synovial fluids contain migration inhibitory factor, blastogenic factor, and B-cell-stimulating factor.
    • These factors are also found in rheumatoid tissue culture supernatants.

    Purpose of the Study:

    • To investigate the origin and in vivo role of lymphokine-like activities in rheumatoid arthritis joints.
    • To understand the contribution of soluble factors to inflammatory arthritis pathogenesis.

    Main Methods:

    • Analysis of synovial fluids and tissue explant culture supernatants from patients with rheumatoid arthritis and other inflammatory joint conditions.
    • Experimental induction of synovitis in rabbit knee joints using lymphokine-rich lymphocyte supernatants.

    Main Results:

    • Macrophage migration inhibitory factor was detected in antigen-induced arthritis in rabbits.
    • Human rheumatoid synovial fluids and rheumatoid tissue cultures showed various lymphokine activities.
    • Injection of lymphokines into rabbit knees induced synovitis with macrophage infiltration and hyperplasia, but lacked lymphocytic and plasmacytic components.

    Conclusions:

    • Soluble factors, particularly lymphokines, likely mediate some pathological changes in active chronic synovitis.
    • Further research is needed to elucidate the precise origin and in vivo functions of these joint-derived lymphokines in rheumatoid arthritis.

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