Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vaccine delivery: lipid-based delivery systems.

M E Baca-Estrada1, M Foldvari, S L Babiuk

  • 1Veterinary Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, S7N 5E3, Saskatoon, Canada. baca@sask.usask.ca

Journal of Biotechnology
|September 23, 2000
PubMed
Summary

Lipid-based delivery systems offer a needle-free vaccine approach, enhancing compliance and reducing trauma. These systems effectively deliver various vaccine types, inducing mucosal or systemic immunity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aerosol delivery of synthetic DNA containing CpG motifs in broiler chicks at hatch under field conditions using a commercial-scale prototype nebulizer provided protection against lethal Escherichia coli septicemia.

Poultry science·2021
Same author

Natural and inducible regulatory B cells are widely distributed in ovine lymphoid tissues.

Veterinary immunology and immunopathology·2019
Same author

Evidence for the existence of regulatory and effector B cell populations in Peyer's patches of sheep.

Veterinary immunology and immunopathology·2016
Same author

Review: Capripoxvirus Diseases: Current Status and Opportunities for Control.

Transboundary and emerging diseases·2015
Same author

Male eyespan size is associated with meiotic drive in wild stalk-eyed flies (Teleopsis dalmanni).

Heredity·2014
Same author

Enhanced immune responses and protection by vaccination with respiratory syncytial virus fusion protein formulated with CpG oligodeoxynucleotide and innate defense regulator peptide in polyphosphazene microparticles.

Vaccine·2012

Area of Science:

  • Biotechnology
  • Vaccinology
  • Drug Delivery Systems

Background:

  • Needle-free vaccine delivery enhances patient compliance and reduces trauma.
  • Lipid-based systems are a promising avenue for needle-free vaccine administration.

Purpose of the Study:

  • To demonstrate the efficacy of lipid-based delivery systems for various vaccine types.
  • To explore the potential of these systems in inducing mucosal and systemic immunity.

Main Methods:

  • Utilized lipid-based delivery systems for recombinant DNA-produced proteins, plasmid-based vaccines, and conventional vaccines.
  • Administered lipid-based systems to mucosal surfaces for mucosal immunity and transdermally for systemic immunity.

Main Results:

Related Experiment Videos

  • Lipid-based systems proved effective for delivering recombinant proteins, plasmid DNA, and conventional vaccines.
  • Successful induction of mucosal immunity via mucosal delivery and systemic immunity via transdermal delivery was achieved.

    • Conclusions:

    • Lipid-based delivery systems are versatile and effective for various vaccine types.
    • These systems hold significant potential to revolutionize vaccine delivery in both human and animal health.