Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

46.6K
Overview
46.6K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

2.5K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.5K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

948
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
948
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

741
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
741
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

611
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
611
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

659
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
659

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes.

Diabetes & metabolism·2020
Same author

Heparin-binding EGF-like growth factor (HB-EGF) antisense oligonucleotide protected against hyperlipidemia-associated atherosclerosis.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2019
Same author

Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk.

Journal of thrombosis and haemostasis : JTH·2018
Same author

Heritability of periodontal bone loss in mice.

Journal of periodontal research·2015
Same author

Zbtb16 has a role in brown adipocyte bioenergetics.

Nutrition & diabetes·2013
Same author

The mouse model for atherosclerosis.

Trends in cardiovascular medicine·2011
Same journal

Daily briefing: 'Cyborg' cockroaches breathe underwater with printed suit.

Nature·2026
Same journal

China boosts prestigious grants for young scientists - will it ease competition?

Nature·2026
Same journal

Incoming US science academy chief vows to 'double down' on research.

Nature·2026
Same journal

Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

Nature·2026
Same journal

Electrodeposited self-assembled molecules for perovskite photovoltaics.

Nature·2026
Same journal

Neutrino's nursery found: the 'Shadow Blaster'.

Nature·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 8, 2013

14.0K

Atherosclerosis.

A J Lusis1

  • 1Department of Medicine, Biology Institute, University of California, Los Angeles 90095, USA. jlusis@mednet.ucla.edu

Nature
|September 23, 2000
PubMed
Summary
This summary is machine-generated.

Atherosclerosis, a major cause of heart disease and stroke, is a complex inflammatory condition. New tools reveal how cholesterol metabolism and risk factors contribute to atherosclerotic plaque development.

More Related Videos

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

1.4K
Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
09:09

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

221

Related Experiment Videos

Last Updated: May 5, 2026

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 8, 2013

14.0K
Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

1.4K
Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
09:09

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

221

Area of Science:

  • Cardiovascular Science
  • Pathology
  • Molecular Biology

Background:

  • Atherosclerosis is a leading cause of death globally, responsible for approximately 50% of all deaths in westernized societies.
  • It is a complex disease with numerous environmental and genetic risk factors, making its cellular and molecular mechanisms challenging to define.
  • Historically viewed as a degenerative process of aging, recent research reframes atherosclerosis as a chronic inflammatory condition.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying atherosclerosis.
  • To understand the connection between altered cholesterol metabolism, other risk factors, and atherosclerotic plaque formation.
  • To differentiate atherosclerosis from a simple consequence of aging and characterize it as an inflammatory disease.

Main Methods:

  • Utilized genetically modified mouse models to study disease development.
  • Applied new investigative tools to analyze cellular and molecular interactions.
  • Integrated findings from epidemiological studies on risk factors.

Main Results:

  • Identified key molecular mechanisms linking cholesterol metabolism and risk factors to atherosclerotic plaque.
  • Demonstrated that atherosclerosis is a chronic inflammatory condition, not solely a degenerative aging process.
  • Established that plaque rupture and thrombosis can precipitate acute clinical events.

Conclusions:

  • Atherosclerosis is a complex inflammatory disease driven by interconnected risk factors and metabolic alterations.
  • Advanced investigative tools, particularly mouse models, have significantly improved understanding of atherosclerotic plaque development.
  • Atherosclerosis requires a paradigm shift from a degenerative view to one recognizing its inflammatory and potentially acute nature.