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[Ticlopidine use in Spain: a pharmacy-based drug utilization study].

A M del Pino1, F J de Abajo, D Montero

  • 1División de Farmacoepidemiología y Farmacovigilancia, Agencia Española del Medicamento, Madrid.

Medicina Clinica
|September 26, 2000
PubMed
Summary

A 1997 program aimed to improve ticlopidine use, but a study found significant off-label prescribing and inadequate monitoring. The initiative did not achieve satisfactory results in Spain.

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Area of Science:

  • Pharmacology
  • Clinical Pharmacy
  • Drug Safety

Background:

  • A program was initiated in 1997 to optimize the clinical application of ticlopidine.
  • This study evaluates the effectiveness of the implemented program.

Purpose of the Study:

  • To assess whether the 1997 program successfully improved ticlopidine utilization.
  • To identify current prescribing patterns and monitoring practices for ticlopidine in Spain.

Main Methods:

  • A cross-sectional study was conducted.
  • Data was collected through pharmacy-based interviews with patients.

Main Results:

  • Out of 346 interviewed patients, 56% received ticlopidine for off-label indications.
  • Dosing discrepancies were observed in 23% of patients, with doses deviating from recommendations.

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  • Only 28% of patients had undergone the recommended fortnightly blood monitoring at the time of the interview.

    • Conclusions:

    • Ticlopidine usage in Spain deviates from its approved product characteristics.
    • The program established to enhance ticlopidine use did not yield satisfactory outcomes.
    • Prescribing and monitoring practices require significant improvement to align with safety guidelines.