[Gastric acid secretion in gastroesophageal reflex disease]

The gastric acid secretion was evaluated by serum pepsinogen I/II ratio and serum Helicobacter pylori IgG antibody titer in gastroesophageal reflux disease(GERD) patient. GERD patients was 81 patients. Los-Angeles classification (LA)O, so called endoscopy negative reflux disease, was 6 patients, and LA-O-B patients was 68 patients. Helicobacter pylori infection ratio in GERD patients was 50.6%(41/81 patients). Pepsinogen I/II ratio in Helicobacter pylori positive GERD patients was no significant different from Helicobacter pylori negative GERD patients. We concluded that the gastric acid secretion in GERD patients was normal secretion.