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Related Experiment Videos

Signaling pathways mediated by tumor necrosis factor alpha.

K G Leong1, A Karsan

  • 1Department of Experimental Medicine, University of British Columbia, Vancouver, Canada.

Histology and Histopathology
|September 27, 2000
PubMed
Summary

Tumor necrosis factor alpha (TNFalpha) initiates signaling pathways leading to cell death or survival gene activation. This review details molecular mechanisms of TNFalpha signal transduction, focusing on apoptosis and transcription factor pathways.

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Area of Science:

  • Cellular Biology
  • Molecular Signaling

Background:

  • Tumor necrosis factor alpha (TNFalpha) is a key cytokine involved in cellular responses.
  • TNFalpha signaling is initiated by receptor binding and subsequent adapter molecule recruitment.
  • TNFalpha triggers diverse cellular outcomes, including apoptosis and gene transcription.

Purpose of the Study:

  • To review the molecular mechanisms of TNFalpha signal transduction.
  • To discuss pathways involved in TNFalpha-induced cell death and transcription factor activation.

Main Methods:

  • Literature review of TNFalpha signaling pathways.
  • Analysis of molecular interactions and cellular responses.

Main Results:

  • TNFalpha signaling involves receptor oligomerization and adapter protein association.

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  • Cellular responses include caspase-dependent and -independent apoptosis.
  • TNFalpha activates transcription factors nuclear factor kappaB (NFkappaB) and activating protein 1 (AP-1).
  • Activated transcription factors regulate genes involved in survival, inflammation, and growth.

    • Conclusions:

    • TNFalpha orchestrates complex signaling networks.
    • Understanding these pathways is crucial for deciphering cellular fate decisions.