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Enterocolitis in children with developmental disorders.

A J Wakefield1, A Anthony, S H Murch

  • 1University Department of Medicine, Royal Free and University College Medical School, London, United Kingdom.

The American Journal of Gastroenterology
|September 28, 2000
PubMed
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Children with developmental disorders often show intestinal pathology, including lymphoid nodular hyperplasia (LNH) and inflammation. This study suggests a new variant of inflammatory bowel disease in these children.

Area of Science:

  • Pediatric Gastroenterology
  • Developmental Pediatrics
  • Gastrointestinal Pathology

Background:

  • Intestinal pathology, such as ileocolonic lymphoid nodular hyperplasia (LNH) and mucosal inflammation, is observed in children with developmental disorders.
  • These gastrointestinal symptoms are often associated with behavioral regression.

Purpose of the Study:

  • To describe the endoscopic and pathological characteristics of the intestine in children with developmental disorders and bowel symptoms.
  • To compare these findings with pediatric controls.

Main Methods:

  • Ileocolonoscopy and biopsy were performed on 60 children with developmental disorders (autism, Asperger's syndrome, etc.) and 37 age-matched controls.
  • Ileal LNH severity was graded, and tissue sections were reviewed by pathologists.

Related Experiment Videos

  • Data were compared with controls and children with ulcerative colitis (UC).

    • Main Results:

    • Ileal LNH was found in 93% of affected children versus 14.3% of controls (p < 0.001).
    • Chronic colitis was identified in 88% of affected children compared to 4.5% of controls (p < 0.001).
    • Inflammation severity scores were significantly higher in affected children and those with UC than in controls.

    Conclusions:

    • The findings suggest a distinct form of inflammatory bowel disease in children with developmental disorders.
    • This variant exhibits significant ileal LNH and chronic colitis.