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Related Experiment Videos

Novel beta-emitting poly(ethylene terephthalate) surface modification.

X Qu1, J Weinberger

  • 1Interventional Cardiology Center, Departments of Medicine and Pharmacology, Columbia University, 161 Fort Washington Avenue, AP-551, New York, New York 10032, USA.

Journal of Biomedical Materials Research
|September 28, 2000
PubMed
Summary

This study presents a novel beta radiation delivery system using chitosan hydrogel on a balloon catheter to prevent arterial restenosis. The system effectively adsorbs phosphorus-32, showing promise for therapeutic applications in preventing repeat procedures.

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Area of Science:

  • Biomaterials Science
  • Interventional Cardiology
  • Radiation Oncology

Background:

  • Arterial restenosis after percutaneous interventions necessitates repeat procedures.
  • Endovascular brachytherapy is effective in preventing restenosis.
  • A novel beta radiation delivery system is needed.

Purpose of the Study:

  • To develop a novel beta radiation delivery system for preventing arterial restenosis.
  • To utilize a pH-sensitive chitosan hydrogel on a poly(ethylene terephthalate) balloon surface for adsorbing beta emitters.
  • To investigate the adsorption efficiency and kinetics of phosphorus-32.

Main Methods:

  • Oxygen plasma treatment of poly(ethylene terephthalate) balloon surface.
  • Coating with pH-sensitive chitosan hydrogel.

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  • Adsorption of phosphorus-32 (o-phosphoric acid) onto the chitosan-coated surface.
  • Surface characterization using attenuated total reflection-Fourier transform infrared spectroscopy and scanning electron microscopy.

    • Main Results:

    • Chitosan hydrogel adhered effectively to the poly(ethylene terephthalate) surface via multiple bond types.
    • Over 70% of o-phosphoric acid was adsorbed onto the sample surface in a 0.2 mM solution.
    • The system demonstrated efficient adsorption of beta emitters.

    Conclusions:

    • A novel beta radiation delivery system based on chitosan hydrogel on a poly(ethylene terephthalate) balloon was successfully developed.
    • The developed system can carry high activity beta emitters.
    • This material holds potential for therapeutic applications in preventing arterial restenosis.