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Efficient asymmetric synthesis of radicicol dimethyl ether: a novel application of ring-forming olefin metathesis
R M Garbaccio1, S J Danishefsky
1The Laboratory for Bioorganic Chemistry, The Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.
Organic Letters
|September 29, 2000
Abstract:
A concise, stereospecific synthesis of radicicol dimethyl ether is presented. The strategy relies on a convergent three-stage assembly of the 14-membered lactone which has, as a key transformation, a novel ring-forming metathesis reaction utilizing a vinyl epoxide.