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Alcoholism: a pharmacogenetic disorder.

G S Omenn

    Modern Problems of Pharmacopsychiatry
    |January 1, 1975
    PubMed
    Summary

    Genetic factors significantly contribute to alcoholism, influencing its effects, metabolism, and complications. Family studies highlight inherited predisposition in developing alcohol use disorder.

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    Area of Science:

    • Behavioral genetics
    • Psychosocial disorders
    • Neuroscience

    Background:

    • Alcoholism is a widespread psychosocial disorder.
    • Genetic factors are increasingly recognized as significant contributors to alcoholism.
    • Understanding genetic predisposition is crucial for prevention and treatment.

    Purpose of the Study:

    • To explore genetically determined differences in alcohol's effects and metabolism.
    • To investigate genetic influences on tolerance, dependence, and addiction.
    • To examine genetic links to alcoholism-related complications and offspring outcomes.

    Main Methods:

    • Analysis of family studies differentiating genetic from environmental influences.
    • Review of data on population subgroups and individuals.
    • Speculative analysis of existing research and data.

    Main Results:

    • Strong evidence for genetic predisposition to alcoholism from family studies.
    • Genetically influenced variations in ethanol effects, metabolism, tolerance, and dependence.
    • Potential genetic links to liver/brain complications and fetal alcohol spectrum disorder.

    Conclusions:

    • Genetic factors play a critical role in alcoholism etiology and manifestation.
    • Individual and subgroup genetic differences impact alcohol response and addiction.
    • Further research into genetic predispositions can inform targeted interventions.

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