Sandifer's syndrome in a breast-fed infant

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G Corrado1, M Cavaliere, P D'Eufemia

  • 1Institute of Pediatrics, University of Rome La Sapienza, Italy.

American Journal of Perinatology
|September 30, 2000
PubMed

Insights

Sandifer's syndrome, a rare condition in infants, may be linked to cow's milk protein allergy. Symptoms resolved in a breast-fed infant after switching to formula, suggesting a dietary trigger.

Area of Science:

  • Pediatrics
  • Gastroenterology
  • Clinical Nutrition

Background:

  • Sandifer's syndrome is a rare condition characterized by abnormal posturing in infants, often associated with gastroesophageal reflux (GER).
  • Literature review indicates a low incidence of breast-feeding among infants diagnosed with Sandifer's syndrome.

Observation:

  • A 15-day-old exclusively breast-fed infant presented with symptoms consistent with Sandifer's syndrome.
  • Diagnostic evaluation confirmed pathological gastroesophageal reflux (GER) via 24-hour esophageal pH monitoring.

Findings:

  • The infant's Sandifer's syndrome symptoms completely resolved upon transitioning to a cow's milk-based formula.
  • This clinical improvement suggests a potential link between breast milk protein content and symptom exacerbation.

Implications:

  • The findings suggest that food allergy to dietary proteins, specifically cow's milk proteins transferred through breast milk, may play a role in Sandifer's syndrome.
  • Further investigation into maternal dietary modifications and hypoallergenic formulas may be beneficial for managing Sandifer's syndrome in breast-fed infants.

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