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Postpartum thyroid dysfunction in women with normal thyroid function during pregnancy.

M Sakaihara1, H Yamada, E H Kato

  • 1Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Sapporo City Institute of Public Health, Sapporo, Japan.

Clinical Endocrinology
|September 30, 2000
PubMed
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Women with antithyroid antibodies who were euthyroid during pregnancy have a high risk of postpartum thyroid dysfunction (PPTD). Further monitoring of thyroid function is recommended for these individuals.

Area of Science:

  • Endocrinology
  • Obstetrics
  • Immunology

Background:

  • Postpartum thyroid dysfunction (PPTD) affects women after childbirth.
  • Identifying risk factors for PPTD is crucial for maternal health.
  • Thyroid function and antibody status during pregnancy are key indicators.

Purpose of the Study:

  • To determine the risk of PPTD in pregnant women with normal thyroid function and no prior thyroid disease.
  • To investigate the association between antithyroid antibodies and PPTD.
  • To assess the likelihood of developing Hashimoto's disease following PPTD.

Main Methods:

  • Screened 4022 pregnant women for thyroid function and antithyroid antibodies.
  • Assessed thyroid function at 1 and 3 months postpartum in 131 antibody-positive and 1030 antibody-negative women.

Related Experiment Videos

  • Measured fT4, TSH, antimicrosome antibody (AMC), and antithyroglobulin antibody (ATG) using dried blood spots.

    • Main Results:

    • PPTD prevalence was 21.3% at 3 months postpartum in antibody-positive women, significantly higher than antibody-negative women (4.7%).
    • 27.3% of women with PPTD and antibodies later developed Hashimoto's disease.
    • High AMC titres were linked to Hashimoto's disease development.

    Conclusions:

    • Women with antithyroid antibodies and normal pregnancy thyroid function have a high prevalence of PPTD.
    • Prolonged postpartum thyroid function monitoring is advised for women with PPTD or high antithyroid antibody titres.