Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Linear extrapolation method of analyzing solvent denaturation curves.

C N Pace1, K L Shaw

  • 1Departments of Medical Biochemistry and Genetics, Biochemistry & Biophysics, and Center for Macromolecular Design, Texas A&M University, College Station, Texas 77843-1114, USA. nickpace@tamu.edu

Proteins
|October 3, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mild radiographic abnormalities of thoracolumbar spinous processes are not associated with decreased performance in 100 Warmblood jumping horses in active competition.

Journal of equine veterinary science·2025
Same author

"Sometimes I feel like a pharmacist": identity and medication use among adolescents with juvenile arthritis.

Pediatric rheumatology online journal·2016
Same author

[Cytotoxicity mechanism of the RNase Sa cationic mutants involves inhibition of potassium current through Ca2+-activated channels].

Molekuliarnaia biologiia·2015
Same author

Immunolocalization of avenin and globulin storage proteins in developing endosperm of Avena sativa L.

Planta·2013
Same author

Walking the talk. Implementation of transitional care guidance in a UK paediatric and a neighbouring adult facility.

Child: care, health and development·2013
Same author

The targets of selection during reinforcement.

Journal of evolutionary biology·2013
Same journal

Engineered HSP90-MP65 Bivalent Fusion Antigen: A Novel Vaccine Candidate Against Invasive Candidiasis.

Proteins·2026
Same journal

Physics-Based Energy Functions for Computational Protein Design.

Proteins·2026
Same journal

Impact of Stabilizing Osmolytes on the Conformational Dynamics of Human and Rat Islet Amyloid Polypeptides.

Proteins·2026
Same journal

Stabilization of Bone Morphogenetic Protein-2 at Physiological pH: Contrasting Roles of CHAPS and Arginine in Aggregation Inhibition.

Proteins·2026
Same journal

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase.

Proteins·2026
Same journal

Generalizing the Gaussian Network Model: Spanning-Tree Thermodynamics Shows Entropy-Driven KRAS Activation.

Proteins·2026
See all related articles

The linear extrapolation method is a key technique for measuring protein conformational stability. This article reviews its history, application in protein stability analysis, and other uses.

Area of Science:

  • Biochemistry
  • Protein Science
  • Biophysical Chemistry

Background:

  • Protein conformational stability is crucial for biological function.
  • Differential scanning calorimetry and solvent denaturation are common measurement methods.
  • The linear extrapolation method offers insights into protein stability.

Purpose of the Study:

  • To provide a historical overview of the linear extrapolation method.
  • To explain the application of the linear extrapolation method in protein stability analysis.
  • To discuss diverse applications of the linear extrapolation method.

Main Methods:

  • Review of historical data and literature.
  • Analysis of solvent denaturation curves.
  • Application of the linear extrapolation method.

Related Experiment Videos

Main Results:

  • The linear extrapolation method has a significant history in protein research.
  • The method is effectively used to determine protein stability.
  • The method has broad applicability beyond initial uses.

Conclusions:

  • The linear extrapolation method is a valuable tool for protein stability assessment.
  • Understanding the history and applications enhances its utility.
  • Further exploration of its uses is warranted.